R305 Fleckvieh Haplotype 2 (FH2)

R305 Categories: ,

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Breed:  Fleckvieh, Braunvieh
Sample material:  Blood EDTA, Blood Heparin, Hair, Semen, Tissue


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Growth retardation due to Fleckvieh Haplotype (FH2) is an autosomal recessive disorder that occurs in Fleckvieh cattle. This causal mutation is located in the SCL2A2 gene. Due to this mutation, the GLUT2 protein, which plays a role in glucose homeostasis, has a deficiency. This leads to retarded growth and failure of the liver and/or kidneys.


Chromosome: 1

Gene: SLC2A2

Mode of Inheritance: Autosomal Recessive

Also known as: FH2

Organ: Multiple systems


Year published: 2015

Clinical Features

Affected cows have decreased/retarded weight gain and show liver and kidney failures. Symptoms will develop in young calves weeks after birth.


Omia: 1958

Pubmed: 25927203