R306 Fleckvieh Haplotype 4 (FH4)

R306 Categories: ,

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Breed:  Fleckvieh
Sample material:  Blood EDTA, Blood Heparin, Hair, Semen, Tissue


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Abortion due to Fleckvieh Haplotype 4 (FH4) is an autosomal recessive disorder that occurs in Fleckvieh cattle. This causal mutation is located in the SUGT1 gene, which encodes for the protein SGT1. The protein SGT1 is part of the cell cycle and a deficiency in this protein will affect the progression of cell-cycle. A deficiency in this process causes early loss of embryos, resulting in reduced fertility of carrier cattle when mated together.


Chromosome: 12

Gene: SUGT1

Mode of Inheritance: Autosomal Recessive Lethal

Also known as: FH4

Organ: Multiple systems


Year published: 2015

Clinical Features

Due to very early loss of affected embryos, pregnancy does not proceed further and the cow will directly enter the next estrous cyclus.


Omia: 1960

Pubmed: 25927203