€ 39,95 ex. VAT
€ 48,34 inc. VAT
10
working days
Demetz Syndrome is a form of degenerative axonopathy (AX), a severe neurological disease that causes muscle weakness, loss of coordination and ultimately death in affected calves. The disorder is found in the Tyrol Grey and the Blanco Orejinegro breeds, and is caused by a recessive mutation to the gene MFN2.
The symptoms of Demetz Syndrome are similar to Weaver Syndrome in Brown Swiss cattle, but occur earlier in life.
Specifications
Chromosome: 16
Gene: MFN2
Mode of Inheritance: Autosomal Recessive
Organ: Nervous system
Sub-organ: Central nervous system
Species:Cattle
Year published: 2011
Clinical Features
The main symptom of Demetz Syndrome in affected calves is ataxia (loss of coordination), which is the most severe in the hind limbs. This results in a wide-limbed stance and easy loss of balance, and affected calves will ultimately be unable to stand. Symptoms start around the first month of age, and affected animals typically have to be slaughtered or euthanized between 8 and 10 months of age.
References
Omia: 1106
Pubmed: 21526202