R520 Bovine Leukocyte Adhesion Deficiency (BLAD)

R520 Categories: ,

 39,95 ex. VAT
 48,34 inc. VAT

Breed:  Blanco Orejinegro, Fleckvieh, Holstein, Jersey Cow
Sample material:  Blood EDTA, Blood Heparin, Hair, Semen, Tissue


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Bovine Leukocyte Adhesion Deficiency (BLAD) in calves is an autosomal recessive disorder. BLAD reduces the expression of certain proteins (Beta 2 integrin) on white blood cells. This reduced expression results in several defects of the function of the white blood cells and thus the imune system of these calves. The disorder is caused by a recessive mutation to the gene ITGB2.

BLAD is related to human LAD, and CLAD in dogs.


Chromosome: 1

Gene: ITGB2

Mode of Inheritance: Autosomal Recessive

Also known as: BLAD, HHB

Organ: Cardiovascular system

Sub-organ: Blood


Year published: 1992

Clinical Features

Affected calves have a compromized immune system and are highly susceptible to (potentially lethal) infections.


Omia: 595

Pubmed: 1384046