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Cow’s milk contains six main proteins that affect its nutritional value: Alpha-casein S1 and S2, beta-casein, kappa-casein, alpha-lactalbumin and beta-lactoglobulin. Various mutations to the genes responsible for forming these proteins can alter its nutritional properties, cheese-making potential, digestibility by human consumers, etc.
This specific test is for a mutation to the beta-lactoglobulin gene PAEP. Beta-lactoglobulin is an important component of milk whey. Increased milk yield and whey protein are associated with high levels of beta-lactoglobulin. The mutation analysed here is responsible for the B allele of beta-lactoglobulin.
Specifications
Chromosome: 11
Gene: PAEP
Mode of Inheritance: Autosomal Co-Dominant
Organ: Endocrine glands
Sub-organ: Mammary glands
Species:Cattle
Year published: 2024
Clinical Features
Cows will produce milk containing a mixture of the beta-lactoglobulin variants they carry. For example, a cow genotyped as B/B will produce pure beta-lactoglobulin B, and a cow genotyped as A/B will produce both beta-lactoglobulin A and B in its milk.
References
Omia: 1437
Pubmed: 38164367