R550 Complex Vertebral Malformation (CVM)

R550 Categories: ,

 39,95 ex. VAT
 48,34 inc. VAT

Breed:  Holstein
Also known as:  CVM, HHC

10

working days

For inquiries about our products or requests for larger volumes of DNA tests, please contact us.
Back to all DNA tests for cattle

Complex Vertebral Malformation (CVM) is a hereditary disorder found primarily in Holstein cattle. It is a skeletal development disorder which can result in malformed, stillborn calves or in spontaneous pregnancy abortions. It is caused by a recessive mutation to the gene SLC35A3.

The disorder has spread considerably through cattle populations worldwide due to the extensive use of elite bulls carrying the mutation.

Additional information

Also known as

Breed

Chromosome

Gene

Mode of Inheritance

Organ

Species

Sub-organ

Year Published

Specifications

Chromosome: 3

Gene: SLC35A3

Mode of Inheritance: Autosomal Recessive

Organ: Skeletal system

Sub-organ: Vertebral column

SpeciesCattle

Year published: 2006

Clinical Features

Affected calves are physically malformed and likely to be stillborn, and euthanasia is likely required for surviving calves on humane and/or livestock management grounds. Typical signs of CVM include a shortened neck, protruding tongue, misshapen head and hernias of the abdomen. Pregnancies carrying affected calves may also spontaneously abort.

References

Omia: 1340

Pubmed: 16344554