R609 Cholesterol Deficiency (CD)
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€ 48,34 inc. VAT
10
working days
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A new autosomal recessive lethal trait, Cholesterol Deficiency (CD) has recently been found in Holstein Cattle. This trait leads to the death of affected calves.
The disorder is caused by a recessive mutation to the gene APOB. The APOB gene encodes apolipoprotein B, which serves as the main apolipoprotein on chylomicrons and low-density lipoproteins. These molecules are responsible for the transport of absorbed lipids (fats) from the intestine to other tissues.
Specifications
Chromosome: 11
Gene: APOB
Mode of Inheritance: Autosomal Recessive Lethal
Also known as: HCD, CDH
Organ: Multiple systems
Species:Cattle
Year published: 2016
Clinical Features
Diarrhea, together with hypocholesterolemia, are symptoms of affected cows. Within the first weeks or months of life, affected cows will die.
References
Omia: 1965
Pubmed: 26763170
