R617 Mulefoot (MF)

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 39,95 ex. VAT
 48,34 inc. VAT

Breed:  Holstein
Sample material:  Blood EDTA, Blood Heparin, Hair, Semen, Tissue


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Mulefoot (MF), also known as Syndactyly, is a developmental disorder in cattle that results in fused hooves. It is caused by a recessive mutation to the gene LRP4. The variant of the mutation analysed in this test occurs primarily in the Holstein. Related variants also occur in the Angus, Simmental and Charolais.


Chromosome: 15

Gene: LRP4

Mode of Inheritance: Autosomal Recessive

Also known as: MF, MFD, SY, HHM

Organ: Skeletal system

Sub-organ: Lower limbs


Year published: 2006

Clinical Features

Affected cattle are born with toes on one or more feet fused together, resulting in singular hooves (much like those of a mule or horse). Walking on fused hooves can be painful and stressful to affected cattle. In addition, cows carrying the mutation have been noted in some cases to have superior milk and butterfat production.


Omia: 963

Pubmed: 16859890