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Mulefoot (MF), also known as Syndactyly, is a developmental disorder in cattle that results in fused hooves. It is caused by a recessive mutation to the gene LRP4. The variant of the mutation analysed in this test occurs primarily in the Holstein. Related variants also occur in the Angus, Simmental and Charolais.
Specifications
Chromosome: 15
Gene: LRP4
Mode of Inheritance: Autosomal Recessive
Also known as: MF, MFD, SY, HHM
Organ: Skeletal system
Sub-organ: Lower limbs
Species:Cattle
Year published: 2006
Clinical Features
Affected cattle are born with toes on one or more feet fused together, resulting in singular hooves (much like those of a mule or horse). Walking on fused hooves can be painful and stressful to affected cattle. In addition, cows carrying the mutation have been noted in some cases to have superior milk and butterfat production.
References
Omia: 963
Pubmed: 16859890