R617 Mulefoot (MF)

R617 Categories: ,

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Breed:  Holstein
Sample material:  Blood EDTA, Blood Heparin, Hair, Semen, Tissue

22

working days

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Mulefoot (MF), also known as Syndactyly, is a developmental disorder in cattle that results in fused hooves. It is caused by a recessive mutation to the gene LRP4. The variant of the mutation analysed in this test occurs primarily in the Holstein. Related variants also occur in the Angus, Simmental and Charolais.

Specifications

Chromosome: 15

Gene: LRP4

Mode of Inheritance: Autosomal Recessive

Also known as: MF, MFD, SY, HHM

Organ: Skeletal system

Sub-organ: Lower limbs

Species:Cattle

Year published: 2006

Clinical Features

Affected cattle are born with toes on one or more feet fused together, resulting in singular hooves (much like those of a mule or horse). Walking on fused hooves can be painful and stressful to affected cattle. In addition, cows carrying the mutation have been noted in some cases to have superior milk and butterfat production.

References

Omia: 963

Pubmed: 16859890