R830 Double Muscling (Myostatin 9 variants)

R830 Categories: ,

 39,95 ex. VAT
 48,34 inc. VAT

Breed:  Aberdeen Angus, Asturian Mountain, Belgian Blue, Blonde d'Aquitaine, Braford, Charolais, Devon, Gascon, Limousin, Maine-Anjou, Marchigiana, Parthenais, Piedmontese
Sample material:  Blood EDTA, Blood Heparin, Hair, Semen, Tissue


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The protein myostatin is essential for proper regulation of myogenesis (the formation of muscle tissue). In cattle, a range of recessive mutations to the myostatin gene (MSTN) results in Muscle Hypertrophy, also known as Double Muscling. Double Muscled cattle, as the name implies, have unusually large muscles, which often goes paired with a lower fat content of their meat. Proper testing for these mutations can be of importance for meat quantity and quality in livestock production.

This combined test analyses for the presence of nine different variant mutations to MSTN. These include variants that are disruptive (C313Y, nt419, E226*, nt821, E291* & Q204*) and variants that are referred to as missense (S105C, F94L & D182N). The disruptive variants cause muscle hypertrophy (double-muscling), larger birth weights, increased dystocia and enhanced tenderness. The missense variants will increase muscularity and reduce external and intramuscular fat, with no change in birth weight or increased chances of dystocia.


Chromosome: 2

Organ: Muscles


Clinical Features

Affected cattle show excessive muscle growth, known as hypertrophy. Variants C313Y, nt419, E226X, nt821, E291X, Q204x result in hypertrophy with higher birth weights, which can lead to dystocia and other birthing difficulties. Variants S105C, F94L and D182N increase muscularity and reduce external and intramuscular fat content, but have not been noted to alter birth weight.

Additional information

Various genetic factors influencing meat quality are inherited in a dominant or recessive mode. Meat quality is influenced by a large number of genetic factors.