R850 Bovine Citrullinemia (BC)

R850 Categories: ,

 39,95 ex. VAT
 48,34 inc. VAT

Breed:  Blanco Orejinegro, Holstein, Braunvieh
Sample material:  Blood EDTA, Blood Heparin, Hair, Semen, Tissue


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Bovine Citrullinemia (BC) is a disorder in the urea cycle that occurs in Holstein cattle. The disorder, caused by a recessive mutation to the gene ASS1, leads to a disruption in the urea cycle and causes a build up of ammonia and other toxic compounds in the blood, resulting in severe neurological symptoms and ultimately death in affected calves.


Chromosome: 11

Gene: ASS1

Mode of Inheritance: Autosomal Recessive

Also known as: BC

Organ: Digestive system

Sub-organ: Liver


Year published: 1989

Clinical Features

Affected calves present with signs of citrullinemia within the first few days after birth. Symptoms include depression, recumbency (inability to rise from a lying position), tremors, seizures, apparent blindness. Coma and death will rapidly follow.


Omia: 194

Pubmed: 2813370