R850 Bovine Citrullinemia (BC)
€ 39,95 ex. VAT
€ 48,34 inc. VAT
10
working days
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Bovine Citrullinemia (BC) is a disorder in the urea cycle that occurs in Holstein cattle. The disorder, caused by a recessive mutation to the gene ASS1, leads to a disruption in the urea cycle and causes a build up of ammonia and other toxic compounds in the blood, resulting in severe neurological symptoms and ultimately death in affected calves.
Specifications
Chromosome: 11
Gene: ASS1
Mode of Inheritance: Autosomal Recessive
Also known as: BC
Organ: Digestive system
Sub-organ: Liver
Species:Cattle
Year published: 1989
Clinical Features
Affected calves present with signs of citrullinemia within the first few days after birth. Symptoms include depression, recumbency (inability to rise from a lying position), tremors, seizures, apparent blindness. Coma and death will rapidly follow.
References
Omia: 194
Pubmed: 2813370
