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Factor XI Deficiency (FXID) is a disorder that affects blood clotting, which can lead to abnormal, excessive bleeding. The disease is caused by a recessive mutation to the gene F11, and is found primarily in the Holstein cow.
Specifications
Chromosome: 27
Gene: F11
Mode of Inheritance: Autosomal Recessive
Also known as: FXID
Organ: Cardiovascular system
Sub-organ: Blood
Species:Cattle
Year published: 2004
Clinical Features
Affected cattle may display a wide range of bleeding abnormalities, including continued bleeding from the umbilical cord in calves, prolonged bleeding after dehorning or castration, and bloody milk. Both carriers and affected cattle may additionally have poorer reproductive performance and an increased vulnerability to infectious diseases.
References
Omia: 363
Pubmed: 15566468