S905 Scrapie Susceptibility – Sheep
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8
working days
Back to all DNA tests for sheep
The disease known as Scrapie is a TSE that affects goats and sheep. Transmissible spongiform encephalopathies (TSEs) are slowly progressive, fatal neurodegenerative diseases which affect a variety of mammalian species. In addition to causing neurodegeneration, they are characterized by formation and accumulation of protease-resistant prion protein mainly in the central nervous system.
In sheep, several different mutations to the gene PrP are known to be relevant. In various combinations, these mutations can greatly influence a sheep’s level of resistance against the disease. The combinations analysed in this test are charted below:
ARR/ARR Resistant
ARR/AHQ Resistant
ARR/ARQ Low risk
ARR/ARH Low risk
AHQ/AHQ Low risk
ARQ/AHQ Low risk
AHQ/ARH Low risk
ARH/ARH Low risk
ARQ/ARH Low risk
ARR/VRQ Low risk
AHQ/VRQ Low risk
ARQ/ARQ High risk
ARQ/VRQ Very high risk
ARH/VRQ Very high risk
VRQ/VRQ Very high risk
Specifications
Chromosome: 13
Gene: PRNP
Mode of Inheritance: Unknown
Organ: Nervous system
Sub-organ: Central nervous system
Species:Sheep
Year published: 1990
Additional information
An animal’s vulnerability to the disease can be influenced by a number of genetic and environmental factors.
References
Omia: 944
Pubmed: 8094373; 1969635
