V302 Embryonic Lethality POLR1B

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Breed:  Landrace
Sample material:  Blood EDTA, Blood Heparin, Hair, Semen, Tissue


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In Landrace pigs, different mutations are known to lead to embryonic lethality or spontaneous abortion. One of these mutations occur in the POLR1B (polymerase (RNA) I polypeptide B, 128kDa) gene, which is involved in the development of the embryo.

An autosomal recessive lethal mutation to the POLR1B gene (also called LA1) is reported to cause embryonic lethality or abortion in Landrace pigs. This mutation leads to a reduction in the number of liveborn offspring in matings between carriers.


Chromosome: 3

Gene: POLR1B

Mode of Inheritance: Autosomal Recessive Lethal

Organ: Multiple systems


Year published: 2019

Clinical Features

This disease is lethal, and results in stillborn animals or embryonic death (i.e. spontaneous abortion). Carriers of the mutation may show increased mothering ability, increased loin depth and amount of meat, lower degree of intramuscular fat in the meat, and/or slower growth compared to non-carriers.


Omia: 2181

Pubmed: 30875370