V303 Embryonic Lethality TADA2A

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Breed:  Duroc
Sample material:  Blood EDTA, Blood Heparin, Hair, Semen, Tissue


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In Duroc pigs, a mutation is known to lead to embryonic lethality or spontaneous abortion. This mutation occurs on the TADA2A (transcriptional adaptor 2A) gene, which is involved in the copying of DNA within the cell.

An autosomal recessive lethal mutation in the TADA2A gene (also called DU1) is reported to cause embryonic lethality or abortion in Duroc pigs. This mutation leads to a reduction in the number of liveborn offspring in matings between carriers.


Chromosome: 12

Gene: TADA2A

Mode of Inheritance: Autosomal Recessive Lethal

Organ: Multiple systems


Year published: 2019

Clinical Features

This disease is lethal to affected embryos, and results in stillborn animals or embryonic death (i.e. spontaneous abortion).


Omia: 2180

Pubmed: 30875370