V304 Embryonic Lethality URB1

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Breed:  Landrace
Sample material:  Blood EDTA, Blood Heparin, Hair, Semen, Tissue


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In Landrace pigs, different mutations are known to lead to embryonic lethality or spontaneous abortion. One of these mutations occur in the URB1 (ribosome biogenesis 1 homolog) gene, which is involved in cellular housekeeping functions essential for embryonic development.

The autosomal recessive semi-lethal loss-of function mutation in the URB1 gene (LA2) is reported to cause embryonic lethality or abortion in Landrace pigs. This mutation leads to a reduction in the number of liveborn offspring.


Chromosome: 13

Gene: URB1

Mode of Inheritance: Autosomal Recessive Lethal

Organ: Multiple systems


Year published: 2019

Clinical Features

This disease is lethal to affected embryos, and results in stillborn animals or embryonic death (i.e. spontaneous abortion).


Omia: 2182

Pubmed: 30875370