V304 Embryonic Lethality URB1
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In Landrace pigs, different mutations are known to lead to embryonic lethality or spontaneous abortion. One of these mutations occur in the URB1 (ribosome biogenesis 1 homolog) gene, which is involved in cellular housekeeping functions essential for embryonic development.
The autosomal recessive semi-lethal loss-of function mutation in the URB1 gene (LA2) is reported to cause embryonic lethality or abortion in Landrace pigs. This mutation leads to a reduction in the number of liveborn offspring.
Specifications
Chromosome: 13
Gene: URB1
Mode of Inheritance: Autosomal Recessive Lethal
Organ: Multiple systems
Species:Pigs
Year published: 2019
Clinical Features
This disease is lethal to affected embryos, and results in stillborn animals or embryonic death (i.e. spontaneous abortion).
References
Omia: 2182
Pubmed: 30875370