V576 Porcine Stress Syndrome (PSS)

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Breed:  All Breeds
Sample material:  Blood EDTA, Blood Heparin, Hair, Semen, Tissue


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Porcine Stress Syndrome (PSS), also known as Malignant Hyperthermia (MH), is an autosomal recessive hereditary disease linked to stress susceptibility and characterized by a neuromuscular disorder. It is caused by a single locus, initially called the halothane gene (HAL) and currently called ryanodine receptor gene RYR1 (ryanodine receptor 1; skeletal).


Chromosome: 6

Gene: RYR1

Mode of Inheritance: Autosomal Recessive

Also known as: PSS

Organ: Multiple systems


Year published: 1991

Clinical Features

The mutation is reported to cause a progressive increase in body temperature, muscle rigidity and metabolic acidosis, leading to rapid death. MH or PSS has the effect that shortly after the slaughter of a pig, the meat quality deteriorates. This is caused by an effect due to stress during e.g. transport.


Omia: 621

Pubmed: 1862346